- Cardarine (GW501515) - 10mg ( Cardarine can increase muscle growth, endurance and aid in fat loss)
- Improves cardiovascular health.
- Burns extra fats quickly.
- Preserves muscle mass.
- Promotes the development of muscle fibres.
- Protects the liver and kidneys from damage.
- Boosts stamina.
Firstly, Cardarine is NOT a SARM but instead is a Peroxisome Proliferator-Activated Receptor Delta (PPARD) receptor agonist. It is often classed or grouped with SARMs from a sales and marketing perspective. The receptor plays an important role in human metabolism and helps regulated genes that help manage the transport and oxidation of fatty acids.
Cardarine captured the attention of the fitness community due to its merits in energy metabolism, by reducing glucose utilisation and increasing fatty acid oxidation. In layman’s terms it triggers the body to burn fat as fuel over glucose. Added to this Cardarine has been shown to improve ATP efficiency and therefore enhance endurance. This was picked up in animal studies when researchers found that mice had greatly increased cardiovascular endurance.
Due to the way Cardarine works users and animal studies showed that Cardarine is associated with significant reduction in body fat. Where Cardarine or GW50515 becomes extremely interesting is that PPARD activation increased mitochondrial biogenesis in the muscle, which can remodel your muscle tissue! In studies of trained and untrained mice, Cardarine caused fast twitch muscle fibre to convert to slow twitch muscle fibres. Because of this Cardarine is often called an exercise mimetic as only exercise could normally make these changes to your metabolism and fibre composition.
In phase 1 and phase 2 trials which lasted 12 weeks 268 patients with low HDL levels were given 2.5,5,10mg daily. During this time good cholesterol improved by 17% and bad cholesterol was reduced by 7%. Bodyweight also increased on average 1.3kg however a LBM vs fat mass analysis was not completed. Due to the way GW1501515 works it is safe to assume it was all or mostly LBM.
In the past there have been rumours based upon speculation regarding tumor growth in the colon. HOWEVER, in 2004 a study published by the American Association of Cancer Research confirmed that Cardarine had shown to have no effect on the proliferation of colorectal cancer cells under normal cultural conditions and PPAR activation has no effect on cell growth. To further this point in 2008 a study was done on human breast cancer and colour cancer cells and not only did the PPAR agonist prove to be safe it was shown to inhibit further cancer cell growth.
Cardarine is normally taken at 10-20mg daily for performance enhancement, for 6-12 weeks.
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