Trainedbyjp TBJP Cure-Coming 60 servings

Trainedbyjp TBJP Cure-Coming 60 servings
Trainedbyjp TBJP Cure-Coming 60 servings

Trainedbyjp TBJP Cure-Coming 60 servings

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TBJP Cure-Coming (60 Servings)

Cure-Coming, an ultra-absorbable curcumin for whole-body health support containing ultra-potent patented BCM-95® Curcumin which has been shown to aid in lowering systemic inflammation, brain/immune/digestive health as well as antioxidant support (60 Servings)

Per Serving

400mg BCM-95® curcumin Tumeric extract

TrainedbyJP Nutrition brings to you Cure-Coming, an ultra-absorbable curcumin for whole-body health support containing ultra-potent patented BCM-95® Curcumin which has been shown to aid in lowering systemic inflammation, brain/immune/digestive health as well as antioxidant support.

Curcumin, the bioactive component of turmeric, Curcuma longa has an exceptionally wide spectrum of activities most notably its antioxidant and anti-inflammatory properties. Most recently, it has also been postulated to have anti-depressive properties in major depressive patients as well as positive cognitive outcomes in older populations.

Curcumin inhibits pro-inflammatory transcription factors such as nuclear factor-kappa beta (NFK- B) which can effect joint inflammation. It also activates peroxisome proliferator–activated receptor gamma (PPAR-γ) and Nrf2 cell signaling pathways, leading to the downregulation of tumor necrosis factor (TNF) and interleukin-6 (IL-6), and upregulates adiponectin (the hormone involved in blood glucose and fatty acid breakdown made by adipose fat tissue).

In simple terms, curcumin has the potential to lower C-Reactive Protein (CRP; a measure of inflammation in the body), induce autophagy through mTOR inhibition (the selective destruction of damaged cellular organelles), protect against cardiac hypertrophy, and potentially decrease artherosclerosis risk.

Despite the promising nutritional and pharmacological properties of curcumin, it exhibits low aqueous solubility, poor gastrointestinal absorption and poor bioavailability.

Its high rate of metabolism, metabolic inactivation and rapid elimination from the body makes it difficult to yield appreciable plasma concentrations. Because of its poor oral absorption, it is difficult for orally administered curcumin to reach blood levels sufficient to exert its bioactivities. Poor absorption from the gut and avid metabolism in the body is cited as reasons for the lack of systemic availability.

To overcome this problem, several curcumin preparations with drug-delivery systems (DDS) have been developed to increase the bioavailability of curcumin after oral administration.

Combinations with piperine have been most common. Piperine, an inhibitor of phase II liver metabolism and intestinal glucuronidation. In rats, the bioavailability of curcumin increased by 154% with piperine compared with a control group without piperine. In humans, piperine (20 mg/kg) was co-administered with curcumin (2 g) and the bioavailability was 20-times that of the control group. However, enhancing bioavailability by inhibiting phase II metabolism must be carefully carried out since many compounds are detoxified through this liver route which may be slowed by adminstering piperine.

BCM-95® is a novel bio-enhanced preparation of curcumin with the addition of phosphatidylcholine and turmeric essential oils (most notably aromatic tumerone volatile oil), which leads to enhanced and sustained absorption. In a human study, 2 g administration showed the bioavailability of BCM-95 (based on curcumin Area Under Curve (AUC)) to be almost 6.93-fold higher than that of a control curcumin formulation with no additive. The half life was shown to be approx. 4.96 h compared to 2.6 h for the control. 2 g/day dose levels are well tolerated without even mild adverse reactions. However, the mechanisms of these enhancements are unknown.

TrainedbyJP Nutrition stands by this long standing patented form of BCM-95® curcumin and we are proud to produce Cure-Coming; a supplement which we believe supports the health of nearly every organ in your body.

Formulated alongside Dr Dean St Mart.

UK Mainland (excluding Highlands and Islands) - All options below
All orders placed before 1p.m. will be processed the same day and delivered accordingly with chosen delivery option. Please note that courier companies work from Monday to Saturday (excluding Bank Holidays).
Orders under £50
1-2 Day delivery (91% delivered next day) if ordered before 1pm. NO SIGNATURE REQUIRED fully tracked. DOES NOT INCLUDE SUNDAYS - £3.49
1-2 Day delivery (91% delivered next day) if ordered before 1pm. SIGNATURE REQUIRED fully tracked. DOES NOT INCLUDE SUNDAYS -  £3.99
FREE Delivery on orders over £50
Orders over £50 can be sent FREE 4-5 day delivery if ordered before 1pm NO SIGNATURE REQUIRED fully tracked. DOES NOT INCLUDE SUNDAYS - FREE
4-5 day delivery if ordered before 1pm SIGNATURE REQUIRED fully tracked. DOES NOT INCLUDE SUNDAYS - FREE
Northern Ireland 
FREE Delivery on orders over £50
We offer FREE 2-3 working day delivery for all orders over £50.00

NI Express delivery is £2.99 and if ordered before 1pm will be delivered next day Mon-Sat only T’s & C’s apply (all our orders will be processed same day if ordered before 1pm. Sometimes the courier can let us down but we guarantee all express items are sent same day if ordered before 1pm).
 
Shipping on orders under £50.00 will be £2.99 and are 1-2 days delivery sent via recorded signed for post.
All orders placed before 1p.m. will be processed the same day and delivered accordingly with chosen delivery option. Please note that courier companies work from Monday to Saturday (excluding Bank Holidays).
 
For queries on shipping times and order status please email hello@nisupplements.com
 
Ireland
Free Ireland delivery on orders over £70.00

We offer free 2-4 working day delivery for all orders over £70.00 if ordered before 1pm excluding weekends.
Orders over £50 will have a reduced rate of £2.99 sent via Parcelforce/GLS and will be a 1-2 day delivery excluding weekends. 
All orders under £50 will get our Express Delivery listed below.

All orders placed before 1p.m. will be processed the same day (excluding weekends) and delivered accordingly with chosen delivery option . Please note that courier companies work from Monday to Friday (excluding Bank Holidays).

Ireland Express delivery is £4.99 and if ordered before 1pm will be delivered next day Mon-Fri only T’s & C’s apply (all our orders will be processed same day if ordered before 1pm. Sometimes the courier can let us down but we guarantee all express items are sent the same day if ordered before 1pm).

Shipping on orders under £50.00 will be £4.99 and are 1-2 day working day delivery sent via Parcelforce/GLS.
 
 

EU & International Shipping
All our International Shipping rates are available at checkout.

Please be aware that if your product is held or delayed in customs we (NI Supplements) or the courier cannot get more updates than what will appear of your tracking info. Customs are an entity of their own as with new Brexit laws they are sometimes extremely slow at processing orders. Any delays outside of our standard stated delivery times due to customs we cannot accept as our responsibility. We cannot contact them to speed up your order. 

 When you Complete your order and tick the checkbox you are accepting the Terms as stated above. Please be aware of this when you are ordering to the EU. 

Please note all delivery time estimates are subject to stock availability and receiving your order by 1pm. Orders placed after 1pm will be processed next working day. Orders are not processed or delivered on weekends and bank holidays.

If an order is returned to us due to customer error (failure to take delivery of the order or arrange a collection/redelivery) then a re-shipping fee is applicable. This is due to the cost of re-packing, and re-shipping that item. A refund of the item minus our shipping costs can be provided as an alternative, but if the error is ours, the item will, of course, be re-shipped at our cost.

 

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