Strom - Quatrefolic
High quality methylfolate supplement, the high dose Quatrefolic® (5-MTHF) dosed at 400μg.
QUATREFOLIC® VS. FOLIC ACID
The body can’t just use folic acid as it is—it has to go through a conversion process into a form called Methyltetrahydrofolate, or MTHF, in order to use it. Quatrefolic® doesn’t go through the same conversion process as folic acid, effectively bypassing that genetic variation.
Take one tablet once daily.
About Quatrefolic®
Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced and active form of folate found in our bodies.
Developed by Gnosis by Lesaffre, Quatrefolic® is the fourth-generation folate, and provides greater stability, higher water solubility and multiple ingredients formulation flexibility compared to 5-methyltetrahydrofolate calcium salt, therefore guaranteeing an improved bioavailability.
As the next-generation solution that bypasses the need for the bioconversion of folic acid in the body, the innovative dietary ingredient functions as a nutrient in all applications where folic acid and active folate supplementation are recommended.
Folic acid vs. active folate: What’s the difference?
While often used interchangeably, folic acid and folate are not the same.
Folic acid is the inactive precursor to active folate, but has historically been used in dietary supplements and fortified foods.
However, to become biologically active, folic acid needs to go through several transformation steps in the body. These conversion steps change folic acid into active folate (known as 5-MTHF) as found in Quatrefolic®.
For a long time, fortified foods and supplements were made with folic acid as the only source of vitamin B9 because it was shown that folic acid is more stable and bioavailable than the forms of folate found in foods.
But new research in the last 10 years has shown that not everybody can convert folic acid to active folate in the same way – meaning that taking supplements containing folic acid can be ineffective for some people.
These people have a specific genetic make-up which means they cannot produce enough of the enzyme that helps convert folic acid into active 5-MTHF folate. This is known as MTHFR polymorphism.
Because the conversion into active folate is not required for reduced and methylated folates like Quatrefolic®, it is a more effective form to take folate than folic acid, which requires conversion. It is also very beneficial for people with MTHFR polymorphism, since they have a lower ability to transform folic acid into the active form of folate.
Delivery Terms & Conditions / Options & Information
Operated by: Nutrition & Internet Supplements Limited (trading as “NI Supplements”)
Registered Office: Unit 5, Graham Industrial Park, Dargan Crescent, Belfast, Co. Antrim, BT3 9LP, United Kingdom
Last updated: 11 October 2025
1. Dispatch & Processing
- Orders placed before 1 p.m. UK time (Monday–Saturday, excluding Bank Holidays) are normally processed and dispatched the same working day.
- Orders placed after this time are processed on the next working day.
- Delivery timeframes exclude Sundays and public holidays unless explicitly stated otherwise.
- Courier network disruptions (e.g., strikes, weather, customs) may extend delivery times beyond our control.
2. Delivery Options – United Kingdom (Mainland & Northern Ireland)
Orders under £50
| Service | Price | Estimated Speed | Notes |
|---|---|---|---|
| 1–2 Day Tracked (No Signature Required) | £2.95 | 1–2 working days (91% next-day) | Fully tracked; photographic & GPS delivery proof confirms delivery. “No Signature Required” terms apply. |
| 1–2 Day Tracked (Signature Required) | £3.35 | 1–2 working days (91% next-day) | Signature obtained on delivery. |
Orders £50 and over
| Service | Price | Estimated Speed | Notes |
|---|---|---|---|
| 4–5 Day Tracked (No Signature Required) | Free | 4–5 working days | Fully tracked; photo/GPS proof confirms delivery. “No Signature Required” terms apply. |
| 4–5 Day Tracked (Signature Required) | Free | 4–5 working days | Signature obtained on delivery. |
3. Delivery Options – Republic of Ireland, EU & International
- Available services, prices and estimated transit times are displayed at checkout.
- Delivery times vary by destination and customs clearance processes.
- Recipients are responsible for any local import duties, taxes, or customs charges.
- We cannot influence or expedite customs procedures in destination countries.
4. Delivery Confirmation, Risk & Transfer of Responsibility
(a) Signature Required
- A signature will be obtained at the point of delivery.
- Until a signed handover occurs, the parcel remains at NI Supplements’ risk.
- Once signed for by you or a nominated recipient, delivery is complete and responsibility transfers to you.
(b) No Signature Required / Authority to Leave
By selecting “No Signature Required” or authorising an unattended delivery / safe place, you:
- Expressly instruct the courier to deliver the parcel to your address or nominated safe place without obtaining a signature.
- Acknowledge that the courier’s photo and GPS confirmation constitute full proof of delivery.
- Accept that once such confirmation is recorded, the order is deemed successfully delivered, and
- Agree that risk of loss, theft or damage passes to you immediately upon that confirmation.
Accordingly, NI Supplements’ delivery obligation is fully discharged once the courier records a delivered scan with accompanying GPS/photo evidence.
If you are concerned about parcel security at your address, please select “Signature Required” at checkout. This is recommended for high-value orders or where the delivery location is unattended or visible from a public street.
5. Non-Delivery Claims
- All non-delivery reports are investigated directly with the courier.
- Where the courier provides proof of delivery (signature, photo or GPS record) matching the supplied address, the order is considered fulfilled and is not eligible for replacement or refund under this policy.
- Where the courier confirms no delivery, we will either resend or refund the order promptly.
6. Failed Delivery, Refusals & Returns to Sender
- If a parcel is returned due to customer error (e.g., incorrect address, failure to collect, or refusal of delivery), we may either:
- Resend it after payment of a re-shipping fee; or
- Refund the product value less the original outbound shipping cost.
- Where the error or delay was caused by NI Supplements or our courier, we will resend at our expense.
7. Same-Day Dispatch Guarantee (Express Orders)
- Guaranteed for orders placed before 1 p.m. (Monday–Saturday).
- Couriers may experience exceptional delays beyond our control; such events do not invalidate the guarantee for dispatch timing.
8. Working Days Definition
“Working Days” means Monday to Saturday, excluding UK Bank Holidays. Orders placed after 1 p.m. on a Saturday or on a Bank Holiday are processed on the next working day.
9. Evidence & Investigation
We maintain courier records, including time-stamped tracking data, GPS coordinates and photographic delivery evidence, for audit and anti-fraud purposes. Customers alleging non-receipt after confirmed delivery may be asked to provide a police crime reference number. We reserve the right to cooperate with carriers and authorities in any fraud investigation.
10. Contact Information
For questions about delivery status or services, please contact:
hello@nisupplements.com
Nutrition & Internet Supplements Limited, Unit 5 Graham Industrial Park, Dargan Crescent, Belfast, Co Antrim, BT3 9LP, United Kingdom.
