Strom - Quatrefolic
High quality methylfolate supplement, the high dose Quatrefolic® (5-MTHF) dosed at 400μg.
QUATREFOLIC® VS. FOLIC ACID
The body can’t just use folic acid as it is—it has to go through a conversion process into a form called Methyltetrahydrofolate, or MTHF, in order to use it. Quatrefolic® doesn’t go through the same conversion process as folic acid, effectively bypassing that genetic variation.
Take one tablet once daily.
About Quatrefolic®
Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced and active form of folate found in our bodies.
Developed by Gnosis by Lesaffre, Quatrefolic® is the fourth-generation folate, and provides greater stability, higher water solubility and multiple ingredients formulation flexibility compared to 5-methyltetrahydrofolate calcium salt, therefore guaranteeing an improved bioavailability.
As the next-generation solution that bypasses the need for the bioconversion of folic acid in the body, the innovative dietary ingredient functions as a nutrient in all applications where folic acid and active folate supplementation are recommended.
Folic acid vs. active folate: What’s the difference?
While often used interchangeably, folic acid and folate are not the same.
Folic acid is the inactive precursor to active folate, but has historically been used in dietary supplements and fortified foods.
However, to become biologically active, folic acid needs to go through several transformation steps in the body. These conversion steps change folic acid into active folate (known as 5-MTHF) as found in Quatrefolic®.
For a long time, fortified foods and supplements were made with folic acid as the only source of vitamin B9 because it was shown that folic acid is more stable and bioavailable than the forms of folate found in foods.
But new research in the last 10 years has shown that not everybody can convert folic acid to active folate in the same way – meaning that taking supplements containing folic acid can be ineffective for some people.
These people have a specific genetic make-up which means they cannot produce enough of the enzyme that helps convert folic acid into active 5-MTHF folate. This is known as MTHFR polymorphism.
Because the conversion into active folate is not required for reduced and methylated folates like Quatrefolic®, it is a more effective form to take folate than folic acid, which requires conversion. It is also very beneficial for people with MTHFR polymorphism, since they have a lower ability to transform folic acid into the active form of folate.
We offer free 2-4 working day delivery for all orders over £70.00 if ordered before 1pm excluding weekends.
All orders placed before 1p.m. will be processed the same day (excluding weekends) and delivered accordingly with chosen delivery option . Please note that courier companies work from Monday to Friday (excluding Bank Holidays).
Ireland Express delivery is £4.99 and if ordered before 1pm will be delivered next day Mon-Fri only T’s & C’s apply (all our orders will be processed same day if ordered before 1pm. Sometimes the courier can let us down but we guarantee all express items are sent the same day if ordered before 1pm).
Shipping on orders under £50.00 will be £4.99 and are 1-2 day working day delivery sent via Parcelforce/GLS.
EU & International Shipping
All our International Shipping rates are available at checkout.
Please be aware that if your product is held or delayed in customs we (NI Supplements) or the courier cannot get more updates than what will appear of your tracking info. Customs are an entity of their own as with new Brexit laws they are sometimes extremely slow at processing orders. Any delays outside of our standard stated delivery times due to customs we cannot accept as our responsibility. We cannot contact them to speed up your order.
When you Complete your order and tick the checkbox you are accepting the Terms as stated above. Please be aware of this when you are ordering to the EU.
Please note all delivery time estimates are subject to stock availability and receiving your order by 1pm. Orders placed after 1pm will be processed next working day. Orders are not processed or delivered on weekends and bank holidays.
If an order is returned to us due to customer error (failure to take delivery of the order or arrange a collection/redelivery) then a re-shipping fee is applicable. This is due to the cost of re-packing, and re-shipping that item. A refund of the item minus our shipping costs can be provided as an alternative, but if the error is ours, the item will, of course, be re-shipped at our cost.
