Strom - Quatrefolic

Strom - Quatrefolic

Strom - Quatrefolic

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High quality methylfolate supplement, the high dose Quatrefolic® (5-MTHF) dosed at 400μg. 

QUATREFOLIC® VS. FOLIC ACID

The body can’t just use folic acid as it is—it has to go through a conversion process into a form called Methyltetrahydrofolate, or MTHF, in order to use it. Quatrefolic® doesn’t go through the same conversion process as folic acid, effectively bypassing that genetic variation.

Take one tablet once daily. 

About Quatrefolic®

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced and active form of folate found in our bodies.  

Developed by Gnosis by Lesaffre, Quatrefolic® is the fourth-generation folate, and provides greater stability, higher water solubility and multiple ingredients formulation flexibility compared to 5-methyltetrahydrofolate calcium salt, therefore guaranteeing an improved bioavailability. 

As the next-generation solution that bypasses the need for the bioconversion of folic acid in the body, the innovative dietary ingredient functions as a nutrient in all applications where folic acid and active folate supplementation are recommended. 

Folic acid vs. active folate: What’s the difference? 

While often used interchangeably, folic acid and folate are not the same.

Folic acid is the inactive precursor to active folate, but has historically been used in dietary supplements and fortified foods.  

However, to become biologically active, folic acid needs to go through several transformation steps in the body. These conversion steps change folic acid into active folate (known as 5-MTHF) as found in Quatrefolic®. 

For a long time, fortified foods and supplements were made with folic acid as the only source of vitamin B9 because it was shown that folic acid is more stable and bioavailable than the forms of folate found in foods.  

But new research in the last 10 years has shown that not everybody can convert folic acid to active folate in the same way – meaning that taking supplements containing folic acid can be ineffective for some people.  

These people have a specific genetic make-up which means they cannot produce enough of the enzyme that helps convert folic acid into active 5-MTHF folate. This is known as MTHFR polymorphism. 

Because the conversion into active folate is not required for reduced and methylated folates like Quatrefolic®, it is a more effective form to take folate than folic acid, which requires conversion. It is also very beneficial for people with MTHFR polymorphism, since they have a lower ability to transform folic acid into the active form of folate. 

Delivery Terms & Conditions / Options & Info

Operated by Nutrition & Internet Supplements Limited (trading as NI Supplements). Last updated: 13 October 2025

Cut-off & processing: Orders placed before 1 p.m. (UK time) are processed the same working day. Courier networks operate Monday–Saturday (excluding Bank Holidays). Delivery times below exclude Sundays unless stated.

UK Mainland (excluding Highlands & Islands)

Orders under £50

Service Price Speed Notes
1–2 Day Delivery (No Signature Required) £2.95 Fully tracked; 91% delivered next day if ordered before 1 p.m. (excl. Sundays) Photographic & GPS delivery proof confirms delivery. Non-delivery claims are investigated; parcels confirmed delivered by Royal Mail are not eligible for replacement.
1–2 Day Delivery (Signature Required) £3.35 Fully tracked; 91% delivered next day if ordered before 1 p.m. (excl. Sundays) Signature required at delivery.

FREE delivery on orders over £50

Service Price Speed Notes
4–5 Day Delivery (No Signature Required) Free Fully tracked (excl. Sundays) Terms for “No Signature Required” (photo/GPS proof) apply.
4–5 Day Delivery (Signature Required) Free Fully tracked (excl. Sundays) Signature required.

Reminder: Selecting “No Signature Required” means your parcel may be left at your address or a designated safe location without a signature, with photo/GPS proof used to confirm delivery.

UK Mainland (excluding Highlands & Islands)

Orders under £50

Service Price Speed Notes
1–2 Day (No Signature) £2.95 Tracked; 91% next-day before 1 p.m. Photo/GPS proof confirms delivery; confirmed deliveries not eligible for replacement.
1–2 Day (Signature) £3.35 Tracked; 91% next-day before 1 p.m. Signature required.

FREE on £50+

Service Price Speed Notes
4–5 Day (No Signature) Free Tracked Photo/GPS proof terms apply.
4–5 Day (Signature) Free Tracked Signature required.
Northern Ireland
Service Price Speed Notes
Free on £50+ Free 2–3 working days Tracked
Express (No Signature) £1.99 Next-day before 1 p.m. Photo/GPS proof
Express (Signature) £2.49 Next-day before 1 p.m. Signature required
Ireland
Service Price Speed Notes
Free on £70+ Free 2–4 working days Tracked; order before 1 p.m.
Reduced Rate on £50+ £2.99 1–2 working days Parcelforce/GLS; tracked
Express under £50 £4.99 Next-day before 1 p.m. Tracked; Mon–Fri dispatch
Standard under £50 £4.99 1–2 working days Parcelforce/GLS; tracked
EU & International

Rates shown at checkout.

Customs: Customs delays are outside our delivery times and not our responsibility; we cannot contact customs to expedite.

General Delivery Terms

  • No Signature Required: By selecting this option you agree your parcel may be left at the delivery address or a designated safe location without a signature. Photographic and GPS proof from the courier confirms delivery. Claims of non-delivery will be investigated, but parcels confirmed delivered are not eligible for replacement.
  • Signature Required: A signature will be obtained at delivery; choose this for added security.
  • Same-day dispatch (express): Guaranteed for orders placed before 1 p.m. Courier delays can occasionally occur.
  • Working days: Processing Mon–Sat (excl. Bank Holidays). Deliveries do not include Sundays unless stated by the service.
  • Cut-off: Orders after 1 p.m. are processed the next working day.

Failed Delivery & Returns to Sender

If an order is returned due to customer error (e.g., failure to take delivery or arrange collection/redelivery), a re-shipping fee applies. Alternatively, a refund of the item price minus our shipping costs can be provided. If the error is ours, we will re-ship at our expense.

Questions about shipping?

For queries on shipping times and order status please email hello@nisupplements.com.

Nutrition & Internet Supplements Limited (trading as NI Supplements)
Unit 5, Graham Industrial Park, Dargan Crescent, Belfast, Co Antrim, BT3 9LP, United Kingdom

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