60 Caps - 10mg GW
- Powerful Anti-Catabolic Compound
- Can be used by MALES and FEMALES!
– Increases Lean Muscle Mass
– Increases Strength & Endurance
– Promotes Fat Loss
– Promotes Recovery
In rats, binding of GW501516 to PPARδ recruits the co activator PGC-1a. The PPARδ/co-activator complex in turn up regulates the expression of proteins involved in energy expenditure. Further more, in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.
GW1516 regulates fat burning through a number of mechanisms. GW1516 increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilisation. This shift changes the body’s metabolism to favour burning fat for energy instead of carbohydrates or muscle protein, potentially allowing fat loss effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar.
GW1516 significantly increases endurance which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW1516 may have a protective effect against obesity.
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