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Cardarine (GW-501516) is an extremely potent PPAR agonist that dramatically increases endurance and fat loss.
Cardarine directly targets the receptors that stimulate glucose uptake and muscle tissue. Because of this it is being suggested as a potential future treatment for obesity due to Cardarine’s ability to quickly cause fatty acid oxidation. It has also been noted that GW-501516 increased HDL (good cholesterol) by 79% and decreased LDL (bad cholesterol).
Cardarine is quickly becoming hailed as the go to supplement for endurance, performance enhancing and fat loss supplement ever. With Cardarine your intensity in the gym will be higher, recovery shorter and you will make plateaus a thing of the past. GW-501516 is not a stimulant and because of this it wont make you anxious, jittery and you wont crash ever. Some people have said that have a greater sense of well being whilst using Cardarine.
Cardarine does not require a PCT, is not liver toxic, can safely be ran by women and can be stacked with all other Muscle Rage fat loss products for even greater results.
Despite everyone singing Cardarine’s praises for endurance, it’s primary purpose is to remove excess body fat from the body. Similar to growth hormone Cardarine causes a pro-inflammatory markers in adipose tissue (tissue in which fat is stored and which has the cells distended by droplets of fat) and decreases the acidity of genes involved in lipogenesis. In non-scientific terms it blocks fatty acid chains from being formed and then stored as fat. GW501516 acts exclusively on the PPAR beta cells that makes the body use fat as fuel as it would when in starvation mode.
The endurance side of this product comes from a study in 2015 which found huge increases in the PPAR gene, in the slow twitch muscle fibres. This caused improved oxygen usage and greatly improved endurance.
When you think that Cardarine cannot get any better it further raises expectations in that no side effects at sensible (no abusive) dosages have been reported. There have been rumours in the past based upon speculation about tumour growth in the colon. HOWEVER, in 2004 a study published by the American Association of Cancer Research confirmed that Cardarine had shown to have no effect on the proliferation of colorectal cancer cells and under normal cultural conditions. PPAR activation has no effect on cell growth. To further this point more in 2008 a study was done on human breast cancer and colour cancer cells and not only the PPAR agonist prove to be safe it was suggested to inhibit further cancer cell growth. In all human studies done there were not noticeable side effects with the use of GW-501516.
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